Molecular Characterization of Copper and Cadmium Resistance Determinants in the Biomining Thermoacidophilic Archaeon Sulfolobus metallicus
Schematic representation of the two cop gene clusters isolated from S. metallicus genome. Each cluster codes for an Archaea-specific transcriptional regulator (copT), a metallochaperone (copM), and a P-type Cu-exporting ATPase (copA). Lengths of each gene are indicated. Locus cop1 corresponds to 4,346 sequenced base pairs and shows an intergenic region copT1-M1 of 232 base pairs. Locus cop2 corresponds to 3,435 base pairs and shows 89 base pairs copT2-M2 intergenic region. Genes copM2 and copA2 overlapped in 11 base pairs. copT2 was not fully isolated.