Comparative Analysis of Proteomes and Functionomes Provides Insights into Origins of Cellular Diversification

Figure 6

Evolutionary timelines highlighting the abundance of FSFs in superkingdom taxonomic groups. Evolutionary age (nd) was calculated from a phylogenetic tree of protein domains describing the evolution of 1,733 FSFs (taxa) in 981 organisms (characters) (see [26, 28, 35] for technical details). SCOP alphanumeric identifiers were used to identify the most ancient FSF in each taxonomic group. In case of multiple FSFs of same age, only the FSF with maximum abundance was labeled. c.37.1 is the P-loop containing NTP hydrolase FSF; b.34.1 is the C-terminal domain of transcriptional repressors FSF; a.267.1 is the topoisomerase V catalytic domain-like FSF; a.253.1 is the AF0941-like FSF; d.2.1 is the Lysozyme-like FSF; a.47.5 is the FlgN-like FSF; b.6.2 is the major surface antigen p30, SAG1.