A Phylogenomic Census of Molecular Functions Identifies Modern Thermophilic Archaea as the Most Ancient Form of Cellular Life
Figure 3
Order of the evolutionary appearance of Venn taxonomic groups. (a) Scatter plot highlighting the distribution of GOTMF terms with respect to evolutionary time (nd) and distribution in genomes (). (b) Boxplots displaying the distribution of GOTMF terms with respect to evolutionary time (nd) in the seven taxonomic groups. The most ancient GOTMF term in each taxonomic group (and outliers) is indexed with numbers 1, “ATP binding [GO: 0005524]”; 2, “DNA replication origin binding [GO: 0003688]”; 3, “penicillin binding [GO: 0008658]”; 4, “2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity [GO: 0008666]”; 5, “UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity [GO: 0008766]”; 6, “chorismate lyase activity [GO: 0008813]”; 7, “CCR1 chemokine receptor binding [GO: 0031726]”; 8, “methylenetetrahydromethanopterin dehydrogenase activity [GO: 0030268]”; and 9, “nicotinamine synthase activity [GO: 0030410]”.
