Understanding DNA Repair in Hyperthermophilic Archaea: Persistent Gaps and Other Reasons to Focus on the Fork

Figure 4

Repositioning of replication errors by fork reversal. If a replication fork reverses shortly after making a replication error, the resulting mismatch would be localized to the short (extruded) arm. In principle, this could provide a basis for removing replication errors without involving a conventional (MutSL-dependent) MMR system. The white semicircle represents a polymerase error; heavy lines depict parental (template) strands.