NADP-Dependent Aldehyde Dehydrogenase from Archaeon Pyrobaculum sp.1860: Structural and Functional Features

Figure 4

Conformations of the active site residues in (a) the apo form, (b) Holo-1, (c) Holo-2, and (d) Holo-3. The coenzyme is in magenta. When the coenzyme is present in the active site, the Glu253, Cys287, and Gly255 residues are in conformations shown in magenta. When there is no coenzyme in the active site, the Glu253, Cys287, and Gly255 residues are in conformations shown in cyan. Hydrogen bonds are shown by dashed lines.

(a)

(b)

(c)

(d)