Metformin Induces Cell Cycle Arrest and Apoptosis in Drug-Resistant Leukemia Cells
Table 2
Cell cycle distribution analysis after metformin treatment.
Control
4 mM
10 mM
CEM
G0/G1
63.87 ± 3.68
54.77 ± 2.63
52.98 ± 0.98
S
27.15 ± 1.48
29.44 ± 0.51
32.66 ± 3.53
G2/M
8.97 ± 2.46
15.79 ± 3.11
14.36 ± 3.72
S + G2/M
36.12 ± 3.67
45.23 ± 2.63
47.02 ± 0.98
10E1-CEM
G0/G1
68.55 ± 2.66
61.31 ± 0.95
49.41 ± 5.63
S
24.69 ± 0.76
32.39 ± 0.62
41.18 ± 6.58
G2/M
6.76 ± 2.51
6.29 ± 1.52
9.41 ± 0.95
S + G2/M
31.45 ± 2.66
38.68 ± 0.95
50.59 ± 5.63
Data are shown as cell percentages on different phases of the cell cycle and represent mean ± SD of three experiments. Differences between treatment and control were significant ().