The primary structure of human preproinsulin. The B1–B23 peptide bound to HLA-DQ8 (A1*03:01-B1*03:02) is shown in red and can be found in Figure 3(a). The peptides bound to HLA-A2 as illustrated in (b), (c), and (d) are shown in blue for C6–C14, C6–C15 as well as for B5–B14.
