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Anatomy Research International
Volume 2013, Article ID 319710, 8 pages
http://dx.doi.org/10.1155/2013/319710
Research Article

Anatomy of the Human Subthalamic Nucleus: A Combined Morphometric Study

1Department of Anatomy, University of Athens, School of Medicine, Mikras Assias street 75, Goudi, 11527 Athens, Greece
22nd Department of Neurosurgery, Attikon Hospital, University of Athens, School of Medicine, Rimini Street 1, Haidari, 12462 Athens, Greece

Received 7 July 2013; Revised 24 October 2013; Accepted 30 October 2013

Academic Editor: David Tai Wai Yew

Copyright © 2013 Ioannis Mavridis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. Our purpose was to provide a combined clinically oriented study focused on the detailed anatomy of the human STN, with great respect to its targeting. Methods. For our imaging study, we used cerebral magnetic resonance images (MRIs) from 26 neurosurgical patients and for our anatomic study 32 cerebral hemispheres from 18 normal brains from cadaver donors. We measured and analyzed the STN dimensions (based on its stereotactic coordinates). Results. At stereotactic level , the STN length was 7.7 mm on MRIs and 8.1 mm in anatomic specimens. Its width was 6 mm on MRIs and 6.3 mm in anatomic specimens. The STN was averagely visible in 3.2 transverse MRI slices and its maximum dimension was 8.5 mm. The intercommissural distance was 26.3 mm on MRIs and 27.3 mm in anatomic specimens. We found statistically significant difference of the STN width and length between individuals <60 and ≥60 years old. Conclusion. The identification of the STN limits was easier in anatomic specimens than on MRIs and easier on T2 compared to T1-weighted MRIs sections. STN dimensions appear slightly smaller on MRIs. Younger people have wider and longer STN.