Table of Contents
Advances in Regenerative Medicine
Volume 2014, Article ID 369498, 14 pages
Review Article

Application of Nanoscaffolds in Mesenchymal Stem Cell-Based Therapy

1Faculty of Basic Sciences, Islamic Azad University of Mahabad, Mahabad 59136, Iran
2Faculty of Basic Sciences, Islamic Azad University of Ahar, Ahar 54511, Iran
3Faculty of Medicine, University of Los Andes, 762001 Santiago, Chile
4Institute of Bioscience, Universiti Putra Malaysia, 43300 Serdang, Selangor, Malaysia
5Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43300 Serdang, Selangor, Malaysia

Received 15 May 2014; Accepted 7 September 2014; Published 23 September 2014

Academic Editor: Mahmood Khan

Copyright © 2014 Saman Ghoraishizadeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Regenerative medicine is an alternative solution for organ transplantation. Stem cells and nanoscaffolds are two essential components in regenerative medicine. Mesenchymal stem cells (MSCs) are considered as primary adult stem cells with high proliferation capacity, wide differentiation potential, and immunosuppression properties which make them unique for regenerative medicine and cell therapy. Scaffolds are engineered nanofibers that provide suitable microenvironment for cell signalling which has a great influence on cell proliferation, differentiation, and biology. Recently, application of scaffolds and MSCs is being utilized in obtaining more homogenous population of MSCs with higher cell proliferation rate and greater differentiation potential, which are crucial factors in regenerative medicine. In this review, the definition, biology, source, characterization, and isolation of MSCs and current report of application of nanofibers in regenerative medicine in different lesions are discussed.