Table of Contents
Advances in Regenerative Medicine
Volume 2014 (2014), Article ID 426520, 8 pages
http://dx.doi.org/10.1155/2014/426520
Review Article

Role of Erythropoietin and Other Growth Factors in Ex Vivo Erythropoiesis

1Stem Cell Research Laboratory, Department of Biotechnology, Delhi Technological University, Shahbad Daulatpur, Bawana Road, Delhi 110042, India
2Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110007, India

Received 28 April 2014; Accepted 9 September 2014; Published 2 October 2014

Academic Editor: Thomas Ichim

Copyright © 2014 Vimal Kishor Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Erythropoiesis is a vital process governed through various factors. There is extreme unavailability of suitable donor due to rare phenotypic blood groups and other related complications like hemoglobinopathies, polytransfusion patients, and polyimmunization. Looking at the worldwide scarcity of blood, especially in low income countries and the battlefield, mimicking erythropoiesis using ex vivo methods can provide an efficient answer to various problems associated with present donor derived blood supply system. Fortunately, there are many ex vivo erythropoiesis methodologies being developed by various research groups using stem cells as the major source material for large scale blood production. Most of these ex vivo protocols use a cocktail of similar growth factors under overlapping growth conditions. Erythropoietin (EPO) is a key regulator in most ex vivo protocols along with other growth factors such as SCF, IL-3, IGF-1, and Flt-3. Now transfusable units of blood can be produced by using these protocols with their set of own limitations. The present paper focuses on the molecular mechanism and significance of various growth factors in these protocols that shall remain helpful for large scale production.