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Volume 2010 (2010), Article ID 130646, 9 pages
Rationale for Targeting CD6 as a Treatment for Autoimmune Diseases
1EA2216 Immunology and Pathology and IFR 148 ScInBioS, European University of Brittany, BP 824, 29609 Brest, France
2Experimental Immunotherapy Department, Center for Molecular Immunology, P.O. Box 16040, 11600 La Havana, Cuba
3Laboratory of Immunology, CHU Brest, Brest University Medical School Hospital, BP 824, 29609 Brest, France
Received 16 August 2010; Accepted 22 December 2010
Academic Editor: Deh-Ming Chang
Copyright © 2010 Ruby Alonso-Ramirez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [13 citations]
The following is the list of published articles that have cited the current article.
- Mafalda Pinto, and Alexandre M. Carmo, “CD6 as a Therapeutic Target in Autoimmune Diseases: Successes and Challenges,” Biodrugs, vol. 27, no. 3, pp. 191–202, 2013.
- Christelle Dantec, Ruby Alonso, Tinhinane Fali, Enrique Montero, Valérie Devauchelle, Alain Saraux, Jacques-Olivier Pers, and Yves Renaudineau, “Rationale for treating primary Sjögren’s syndrome patients with an anti-CD6 monoclonal antibody (Itolizumab),” Immunologic Research, 2013.
- M. Wagner, M. Bilinska, A. Pokryszko–Dragan, M. Sobczynski, M. Cyrul, P. Kusnierczyk, and M. Jasek, “ALCAM and CD6 – multiple sclerosis risk factors,” Journal of Neuroimmunology, 2014.
- Lazaro E. Aira, Alejandro Lopez-Requena, Dasha Fuentes, Liset Sanchez, Teresita Perez, Aleida Urquiza, Heber Bautista, Leopoldina Falcon, Patricia Hernandez, and Zaima Mazorra, “Immunological and histological evaluation of clinical samples from psoriasis patients treated with anti-CD6 itolizumab,” Mabs, vol. 6, no. 3, pp. 782–792, 2014.
- D.S. Krupashankar, Sunil Dogra, Mahendra Kura, Abir Saraswat, Leelavathy Budamakuntla, T.K. Sumathy, Radha Shah, M.G. Gopal, T. Narayana Rao, Enrique Montero, M.S. Ramakrishnan, Pradip Nair, and Prasanna C. Ganapathi, “Efficacy and safety of itolizumab, a novel anti-CD6 monoclonal antibody, in patients with moderate to severe chronic plaque psoriasis: Results of a double-blind, randomized, placebo-controlled, phase-III study,” Journal of the American Academy of Dermatology, 2014.
- Arvind Chopra, S. Chandrashekara, Rajgopalan Iyer, Liza Rajasekhar, Naresh Shetty, Sarathchandra Mouli Veeravalli, Alakendu Ghosh, Mrugank Merchant, Jyotsna Oak, Vikram Londhey, Abhijit Barve, M. S. Ramakrishnan, and Enrique Montero, “Itolizumab in combination with methotrexate modulates active rheumatoid arthritis: safety and efficacy from a phase 2, randomized, open-label, parallel-group, dose-ranging study,” Clinical Rheumatology, 2015.
- Christelle Le Dantec, Sophie Vallet, Wesley Brooks, and Yves Renaudineau, “Human Endogenous Retrovirus Group E and Its Involvement in Diseases,” Viruses, vol. 7, no. 3, pp. 1238–1257, 2015.
- Javier Gutierrez-Achury, Maria Magdalena Zorro, Isis Ricaño-Ponce, Daria V. Zhernakova, Dorothée Diogo, Soumya Raychaudhuri, Lude Franke, Gosia Trynka, Cisca Wijmenga, and Alexandra Zhernakova, “Functional implications of disease-specific variants in loci jointly associated with coeliac disease and rheumatoid arthritis,” Human Molecular Genetics, vol. 25, no. 1, pp. 180–190, 2015.
- Lazaro E. Aira, Patricia Hernández, Dinorah Prada, Araceli Chico, Jorge A. Gómez, Zuyén González, Karla Fuentes, Carmen Viada, and Zaima Mazorra, “Immunological evaluation of rheumatoid arthritis patients treated with itolizumab,” mAbs, pp. 00–00, 2015.
- Diana Markozashvili, Andrei Pichugin, Ana Barat, Valerie Camara-Clayette, Natalia V. Vasilyeva, Hélène Lelièvre, Laurence Kraus-Berthier, Stéphane Depil, Vincent Ribrag, and Yegor Vassetzky, “Histone deacetylase inhibitor abexinostat affects chromatin organization and gene transcription in normal B cells and in mantle cell lymphoma,” Gene, 2016.
- Marion H. Brown, “CD6 as a Cell Surface Receptor and As a Target for Regulating Immune Responses,” Current Drug Targets, vol. 17, no. 6, pp. 619–629, 2016.
- David M. Kofler, Aron Farkas, Michael von Bergwelt-Baildon, and David A. Hafler, “The Link Between CD6 and Autoimmunity: Genetic and Cellular Associations,” Current Drug Targets, vol. 17, no. 6, pp. 651–665, 2016.
- Sunil Dogra, Shraddha Uprety, and Swaroop Hassan Suresh, “Itolizumab, a novel anti-CD6 monoclonal antibody: a safe and efficacious biologic agent for management of psoriasis,” Expert Opinion on Biological Therapy, pp. 1–8, 2017.