Serum Leptin Concentration Positively Correlates with Body Weight and Total Fat Mass in Postmenopausal Japanese Women with
Osteoarthritis of the Knee
Table 1
Characteristics of study subjects.
Mean ± SD
Range
Age (years)
50–88
Height (m)
1.47–1.65
Body weight (kg)
44–80
Body mass index (kg/m2)
16.9–33.3
Lumbar spine BMD (g/cm2)
0.524–1.316
Whole body BMD (g/cm2)
0.647–1.109
Lean body mass (g)
20720–64203
Total fat mass (g)
14302–41201
Total fat percent (%)
29.7–51.5
Serum BAP (U/L)
11.7–49.8
Serum OC (ng/mL)
1.7–11.9
Urinary pyridinoline (pmol/μmol Cr)
19.3–63.6
Urinary deoxypyridinoline (nmol/mmol Cr)
2.8–10.1
Urinary NTX (nmol BCE/mmol Cr)
8.2–95.7
Serum leptin (ng/mL)
1.8–21.1
Radiographic grade
1–4
BMD: bone mineral density, BAP: bone-specific alkaline phosphatase, OC: osteocalcin, NTX: cross-linked N-terminal telopeptides of type I collagen, BCE: bone collagen equivalent, Cr: creatinine. Normal ranges of urinary pyridinoline, deoxypyridinoline, and NTX were 17.7–41.9 pmol/μmol Cr and 2.8–7.6 nmol/mmol Cr, and 9.3–54.3 nM BCE/mM Cr, respectively. Normal ranges of serum BAP, OC, and leptin were 7.9–20.9 U/L, 3.1–12.7 ng/mL, and 2.5–21.8 ng/mL, respectively.