Defects in Tendon, Ligament, and Enthesis in Response to Genetic Alterations in Key Proteoglycans and Glycoproteins: A Review

Figure 3

Decorin deficiency results in aberrant tendon collagen fibril structure. TEM of tail tendon of 7.5-month old mice showing transverse section of collagen fibrils. A larger fraction of fibrils are noncylindrical and structurally aberrant in homozygous mutant (𝐷𝑐𝑛^−/−, (b)) as compared to WT (𝐷𝑐𝑛^+/+, (a)) mouse (Reprinted from Zhang et al., 2006 [33], copyright © 2005 Wiley-Liss, Inc. with permission).