Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population

Table 1

The summary of radiographic knee OA evaluation and characteristics of study group.

	OA in TFJ			OA in PFJ			OPH
	Grade 0; (𝑁=211)	Grade 1; (𝑁=188)	Grade 2-3; (𝑁=39)	Grade 0; (𝑁=226)	Grade 1; (𝑁=177)	Grade 2-3; (𝑁=35)	Grade 0; (𝑁=185)	Grade 1; (𝑁=205)	Grade 2-3; (𝑁=48)
Females, %	68	71	67	68	73	62	67	73	63
Age; Mean (±SD)	44.3 (5.9)	46.1 (5.5)	48.2 (5.5)*	44.3 (6.0)	46.5 (5.3)	47.6 (5.4)*	44.4 (5.9)	4.9 (5.5)	47.9 (5.6)*
BMI; Mean (±SD)	25.9 (4.6)	28.6 (4.8)	30.1 (5.7)*	26.3 (4.6)	28.2 (5.2)	29.3 (5.5)*	25.6 (4.5)	28.2 (4.5)	29.8 (5.3)*

OA in TFJ: radiographic osteoarthritis in tibiofemoral joint; OA in PFJ: radiographic osteoarthritis in patellofemoral joint; OPH: osteophytes; BMI: body mass index; ∗P value < 0.001 (compared to the group with radiographic stage 0).