Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population

Table 3

Statistically significant association of rs1871054 in ADAM12 gene with advanced (grade ≥ 2) knee radio features (were found only on males).


	Grade 0	Grade ≥ 2	OR (95% CI)	P value	Corrected P value**

rs1871054, males	OA

C allele	44%	68%	2.82 (1.20–6.67)	0.018	0.038
CC	8 (16%)	10 (50%)	7.86 (1.30–47.69)	0.025	0.052
CT	29 (57%)	7 (35%)	1.39 (0.28–7.02)	NS
TT	14 (27%)	3 (15%)	1*	1*

rs1871054, males	OPH

C allele	45%	70%	2.67 (1.11–6.44)	0.029	0.06
CC	11 (18%)	8 (61%)	5.31 (0.94–29.87)	NS
CT	33 (55%)	5 (38%)	1.01 (0.19–5.48)	NS
TT	16 (27%)	3 (23%)	1*	1*

rs1871054, males	OA in TFJ

C allele	48%	73%	3.82 (1.36–10.73)	0.011	0.023
CC	12 (18%)	8 (62%)	10.11 (1.29–79.45)	0.028	0.058
CT	35 (53%)	3 (23%)	1.26 (0.17–9.54)	NS
TT	19 (29%)	2 (15%)	1*	1*

rs1871054, males	OPH in TFJ

C allele	47%	73 %	3.03 (1.11–7.53)	0.018	0.038
CC	15 (20%)	8 (53%)	6.63 (1.15–38.17)	0.034	0.07
CT	39 (53%)	5 (323%)	1.66 (0.30–9.40)	NS
TT	20 (27%)	2 (15%)	1*	1*

OA: global grade of radiographic knee OA in tibiofemoral joint and/or patellofemoral joint; TFJ: tibiofemoral joint; OPH: osteophytes; TT genotypes were analysed as base; for multiple comparison correction Benjamini and Yekutieli method was used; in bold are shown statistically significant P values.

Arthritis

Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population

Table 3