Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population
Table 3
Statistically significant association of rs1871054 in ADAM12 gene with advanced (grade ≥ 2) knee radio features (were found only on males).
Grade 0
Grade ≥ 2
OR (95% CI)
P value
Corrected P value**
rs1871054, males
OA
C allele
44%
68%
2.82 (1.20–6.67)
0.018
0.038
CC
8 (16%)
10 (50%)
7.86 (1.30–47.69)
0.025
0.052
CT
29 (57%)
7 (35%)
1.39 (0.28–7.02)
NS
TT
14 (27%)
3 (15%)
1*
1*
rs1871054, males
OPH
C allele
45%
70%
2.67 (1.11–6.44)
0.029
0.06
CC
11 (18%)
8 (61%)
5.31 (0.94–29.87)
NS
CT
33 (55%)
5 (38%)
1.01 (0.19–5.48)
NS
TT
16 (27%)
3 (23%)
1*
1*
rs1871054, males
OA in TFJ
C allele
48%
73%
3.82 (1.36–10.73)
0.011
0.023
CC
12 (18%)
8 (62%)
10.11 (1.29–79.45)
0.028
0.058
CT
35 (53%)
3 (23%)
1.26 (0.17–9.54)
NS
TT
19 (29%)
2 (15%)
1*
1*
rs1871054, males
OPH in TFJ
C allele
47%
73 %
3.03 (1.11–7.53)
0.018
0.038
CC
15 (20%)
8 (53%)
6.63 (1.15–38.17)
0.034
0.07
CT
39 (53%)
5 (323%)
1.66 (0.30–9.40)
NS
TT
20 (27%)
2 (15%)
1*
1*
OA: global grade of radiographic knee OA in tibiofemoral joint and/or patellofemoral joint; TFJ: tibiofemoral joint; OPH: osteophytes; TT genotypes were analysed as base; for multiple comparison correction Benjamini and Yekutieli method was used; in bold are shown statistically significant P values.
