Table 3: Statistically significant association of rs1871054 in ADAM12 gene with advanced (grade ≥ 2) knee radio features (were found only on males).

Grade 0 Grade ≥ 2 OR (95% CI) P value Corrected P value** rs1871054, males OA   C allele 44% 68% 2.82 (1.20–6.67) 0.018 0.038 CC 8 (16%) 10 (50%) 7.86 (1.30–47.69) 0.025 0.052 CT 29 (57%) 7 (35%) 1.39 (0.28–7.02) NS   TT 14 (27%) 3 (15%) 1* 1*   rs1871054, males OPH       C allele 45% 70% 2.67 (1.11–6.44) 0.029 0.06 CC 11 (18%) 8 (61%) 5.31 (0.94–29.87) NS   CT 33 (55%) 5 (38%) 1.01 (0.19–5.48) NS   TT 16 (27%) 3 (23%) 1* 1*   rs1871054, males OA in TFJ       C allele 48% 73% 3.82 (1.36–10.73) 0.011 0.023 CC 12 (18%) 8 (62%) 10.11 (1.29–79.45) 0.028 0.058 CT 35 (53%) 3 (23%) 1.26 (0.17–9.54) NS   TT 19 (29%) 2 (15%) 1* 1*   rs1871054, males OPH in TFJ       C allele 47% 73 % 3.03 (1.11–7.53) 0.018 0.038 CC 15 (20%) 8 (53%) 6.63 (1.15–38.17) 0.034 0.07 CT 39 (53%) 5 (323%) 1.66 (0.30–9.40) NS   TT 20 (27%) 2 (15%) 1* 1*

OA: global grade of radiographic knee OA in tibiofemoral joint and/or patellofemoral joint; TFJ: tibiofemoral joint; OPH: osteophytes; TT genotypes were analysed as base; for multiple comparison correction Benjamini and Yekutieli method was used; in bold are shown statistically significant P values.