Research Article

Fibroblast-Like Synoviocytes Induce Calcium Mineral Formation and Deposition

Table 1

Genes differentially expressed in hTERT-OA 13A FLSs compared with hTERT-RA 516 FLSs.

Biological processGene nameDifferential expression (fold)*Description

Biomineral formationIGSF1010.97Immunoglobulin superfamily, member 10
CHRDL18.40Chordin-like 1
TWIST25.21Twist homolog 2 (Drosophila)
RUNX22.26Runt-related transcription factor 2
ENPP11.95Ectonucleotide pyrophosphatase/phosphodiesterase 1
BGLAP1.87Bone gamma-carboxyglutamate (gla) protein (osteocalcin)
BMPR1B1.87Bone morphogenetic protein receptor, type IB
COL13A11.85Collagen, type XIII, alpha 1
FGF9−29.84Fibroblast growth factor 9 (glia-activating factor)
PTGER4−10.03Prostaglandin E receptor 4 (subtype EP4)
EGFR−5.57Epidermal growth factor receptor
ANKH−5.26Ankylosis, progressive homolog (mouse)
CTGF−4.99Connective tissue growth factor
PTN−4.67Pleiotrophin
ADRB2−4.45Adrenergic, beta-2-, receptor, surface
TGFB2−4.12Transforming growth factor, beta 2
TGFB3−3.07Transforming growth factor, beta 3
TGFB1−2.16Transforming growth factor, beta 1
PTHLH−3.61Parathyroid hormone-like hormone
BMP6−3.49Bone morphogenetic protein 6
BMP4−2.86Bone morphogenetic protein 4
MEF2C−3.18Myocyte enhancer factor 2C
CDK6−3.13Cyclin-dependent kinase 6
FOXC1−3.02Forkhead box C1
TNFRSF11A−2.35Tumor necrosis factor receptor superfamily, member 11a
AXIN2−2.31Axin 2 (conductin, axil)
GNAS−2.13GNAS complex locus
SORT1−2.00Sortilin 1
TUFT1−1.91Tuftelin 1
SRGN−1.90Serglycin
GLI2−1.82GLI-Kruppel family member GLI2

Positive number indicates elevated expression (fold) in hTERT-OA 13A FLSs compared with hTERT-RA 516 FLSs.
Negative number indicates decreased expression (fold) in hTERT-OA 13A FLSs compared with hTERT-RA 516 FLSs.