The Safety and Efficacy of an Enzyme Combination in Managing Knee Osteoarthritis Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

Table 2

Lequesne Functional Index total scores.

	Median score		Median; change	Median; % change
	Baseline	Week 12
Diclofenac	13.0^1	8.3	−4.0^*A	−32.7^*A
	(12.0, 13.0)	(7.0, 10.0)	(−5.5, −2.0)	(−42.3, −22.8)
Wobenzym	12.0	9.0	−3.3^*A	−27.4^*A
	(11.5, 13.0)	(8.0, 10.0)	(−4.5, −2.0)	(−35.7, −16.7)
Placebo	12.5	9.8	−2.0^*B	−16.4^*B
	(12.0, 12.5)	(9.0, 11.5)	(−3.5, −0.5)	(−28.0, −4.8)

All values presented as median (95% confidence interval).
^*Significantly different from “no change” ( < 0.05).
^A,BTreatment groups with different superscripts differ within the same column ( < 0.05).