The Safety and Efficacy of an Enzyme Combination in Managing Knee Osteoarthritis Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

Table 5

Adverse events resulting in discontinuation of treatment.

Treatment group	Gender	Adverse events
Diclofenac	F	Nausea
	F	Diarrhea
	F	Acute leukocytosis
	F	Eczema
	F	Stomach pain
	M	Edema
Wobenzym	F	Heartburn
	M	Stomach pain
	M	Back pain
	M	Stomach pain accompanied by gastroesophageal reflux and nausea
Placebo	F	Nausea
	F	Nausea
	F	Edema of legs
	M	Flatulence and diarrhea
	M	Abnormal laboratory results
	M	Stomach pain and episodes of vertigo