A Systematic Review Investigating the Presence of Inflammatory Synovitis in Hip and Knee Joint Replacement Surgery

Table 3

Genes differentially expressed between normal/reactive and inflamed areas of synovium.

Compound	Upregulated	Downregulated
Inflammatory cytokines	IL8, IL6, TNFRSF21, IFI30, TNFAIP6, and IRF8
Inflammatory chemokines	CXCL5, CXCL6, CXCL16, CXCL2, and CXCL1
Inflammatory enzymes	ALOX5AP, PLD1, ALOX5, PTGES, PLCB1, SOD2, TBXAS1, PI3, and PLA2G4A
Other inflammatory compounds	TREM1, S100A9, OSM, and PPARG
Anabolism	HAS1, BMP6, and COLL22A1	COL1A2, VIM, MATN2, HABP4, HAPLN1, HAS3, COL16A1, CILP, COL6A3, GPC4, HAPLN1, and ACAN
Catabolism	MMP9, MMP3, CTSH, ADAMDEC1, and CTSS
Angiogenesis	STC1, PF4V1, EDNRB, AQP9, HBEGF, BDKRB1, RCAN1, ECGF1, DNER, BDKRB2, and PECAM1	PDGFC and RNH1

IL: Interleukin, TNFRS: tumour necrosis factor receptor, and IFI30: gene for encoding Gamma-interferon-inducible lysosomal thiol reductase. TNFAIP6: tumor necrosis factor alpha-induced protein 6, IRF: interferon regulatory factor, CXCL: chemokine ligand, and ALOX5AP: 5-lipoxygenase activating protein encoded by the ALOX5AP gene. PLD: phospholipase D1 enzyme that is encoded by the PLD1 gene, PTGES: prostaglandin E synthase is an enzyme encoded by the PTGES gene, PLCB1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1 is an enzyme encoded by the PLCB1 gene, and SOD2: superoxide dismutase 2 enzyme encoded by the SOD2 gene. TBXAS1: thromboxane A synthase 1 enzyme encoded by the TBXAS1 gene, PI3: elafin, PLA2G4A: cytosolic phospholipase A2 enzyme encoded by the PLA2G4A gene, TREM1: triggering receptor expressed on myeloid cells 1 protein encoded by the TREM1 gene, S100A9: migration inhibitory factor-related protein 14, OSM: oncostatin M, PPARG: peroxisome proliferator-activated receptor gamma, HAS1: hyaluronan synthases 1, BMP: bone morphogenetic protein, COL: collagen, VIM: vimentin, MATN: cartilage matrix protein, HABP: hyaluronan-binding protein, HAPLN: proteoglycan link protein, HAS: hyaluronan synthase, CILP: intermediate layer protein, GPC: cerebroglycan, ACAN: aggrecan, MMP: metalloproteinase, CTSH: cathepsin H, ADAMDEC1: ADAM-like, decysin 1, CTSS: cathepsin S, STC1: stanniocalcin-1, EDNRB: endothelin receptor type B, AQP9: aquaporin-9, HBEGF: heparin-binding EGF-like growth factor, BDKRB1: bradykinin receptor B1, RCAN1: Down syndrome critical region gene 1, ECGF1: platelet-derived endothelial cell growth factor, DNER: Delta and Notch-like epidermal growth factor-related receptor, BDKRB2: bradykinin receptor B2, PECAM1: platelet endothelial cell adhesion molecule, PDGFC: platelet-derived growth factor C, and RNH1: ribonuclease inhibitor.