Research Article
Amtolmetin: A Reappraisal of NSAID with Gastroprotection
Table 3
Comparisons of adverse events in different trials.
| | | Bianchi Porro et al. [8] | Montrone et al. [6] | Jajić et al. [4] | value | | | AMG | Diclofenac | AMG | Piroxicam | AMG | Celecoxib |
| | Patients evaluated, | 32 | 32 | 49 | 50 | 85 | 95 | | | GI symptoms, (%) | 17 (53.1) | 14 (43.8) | 18 (36.7) | 20 (40) | 45 (52.9) | 57 (60) | >0.05 | | Serious AEs related to the drug leading to withdrawal, (%) | 3 (9.4) | 5 (15.6) | 2 (4.1) | 9 (18) | 0 (0) | 1 (1.1) | <0.051 | | Cases of severe gastric and/or duodenal ulcer after treatment, (%) | 1 (3.1) | 8 (25) | NE | 4 (4.7) | 10 (10.5) | <0.05 | | Patients with very high endoscopy score, (%) | 4 (12.5) | 14 (43.8) | NE | 21 (24.7) | 21 (22.1) | <0.05 |
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NE: not evaluated.
1Additionally post hoc test was performed which gave similar results.
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