Table of Contents
Advances in Toxicology
Volume 2014 (2014), Article ID 201762, 9 pages
http://dx.doi.org/10.1155/2014/201762
Research Article

Modulation of Tinospora rumphii and Zinc Salt on DNA Damage in Quinoline-Induced Genotoxicity and Hepatotoxicity in Male Albino Mice

1Field of Drug Discovery Research, Faculty of Advanced Life Science, Hokkaido University, N21, W10, Kita-ku, Sapporo 001-0021, Japan
2Chemistry Department, Xavier University-Ateneo de Cagayan, 9000 Cagayan de Oro City, Philippines
3Chemistry Department, College of Science and Mathematics, Mindanao State University-Iligan Institute of Technology, 9200 Iligan City, Philippines

Received 12 August 2014; Accepted 30 October 2014; Published 20 November 2014

Academic Editor: Mugimane Manjanatha

Copyright © 2014 Roger Salvacion Tan and Lydia M. Bajo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C.-T. Ruan, S.-H. Lam, T.-C. Chi, S.-S. Lee, and M.-J. Su, “Borapetoside C from Tinospora crispa improves insulin sensitivity in diabetic mice,” Phytomedicine, vol. 19, no. 8-9, pp. 719–724, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. L. R. Zafinindra, W. Diatta, A. M. Dieye, R. Nongonierma, B. Faye, and E. Bassene, “Antipyretic effect of aqueous extract and alcaloid of Tinospora bakis (Miers) in rabbits,” Dakar Medical, vol. 48, no. 1, pp. 29–33, 2003. View at Google Scholar · View at Scopus
  3. E. Quisumbing, Medicinal Plants of the Philippines, pp. 300-301, Bureau of Printing, Manila, Philippines, 1951.
  4. J. Concha, Philippine National Formulary (Medicinal Plants), National Science Development Board, Manila, Philippines, 1982.
  5. L. S. De Padua, G. C. Lugod, and J. V. Pancho, Handbook on Philippine Medicinal Plants, Documentation and Information Section, Office of the Director of Research, University of the Philippines at Los Banos, Manila, Philippines, 1981.
  6. C. Murakami, K. Myoga, R. Kasai et al., “Screening of plant constituents for effect on glucose transport activity in Ehrlich ascites tumor cells,” Chemical and Pharmaceutical Bulletin, vol. 41, no. 12, pp. 2129–2131, 1993. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Noor and S. J. H. Ashcroft, “Antidiabetic effects of Tinospora crispa in rats,” Journal of Ethnopharmacology, vol. 27, no. 1-2, pp. 149–161, 1989. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Cavin, K. Hostettmann, W. Dyatmyko, and O. Potterat, “Antioxidant and lipophilic constituents of Tinospora crispa,” Planta Medica, vol. 64, no. 5, pp. 393–396, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. J. C. Arcos and M. F. Argus, “Chemical induction of cancer,” in Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, vol. IIB, pp. 93–111, Academic Press, New York, NY, USA, 1974. View at Google Scholar
  10. U.S. Department of Health and Human Services, Registry of Toxic Effects of Chemical Substances (RTECS, Online Database), National Toxicology Information Program, National Library of Medicine, Bethesda, Md, USA, 1993.
  11. K. Hirao, Y. Shinohara, H. Tsuda, S. Fukushima, and M. Takahashi, “Carcinogenic activity of quinoline on rat liver,” Cancer Research, vol. 36, no. 2, pp. 329–335, 1976. View at Google Scholar · View at Scopus
  12. R. Hasegawa, F. Furukawa, K. Toyoda, H. Sato, K. Imaida, and M. Takahashi, “Sequential analysis of quinoline-induced hepatic hemangioendothelioma development in rats,” Carcinogenesis, vol. 10, no. 4, pp. 711–716, 1989. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Asakura, S. Sawada, T. Sugihara, H. Daimon, and F. Sagami, “Quinoline-induced chromosome aberrations and sister chromatid exchanges in rat liver,” Environmental and Molecular Mutagenesis, vol. 30, pp. 459–467, 1997. View at Google Scholar
  14. E. J. LaVoie, S. Dolan, P. Little, C.-X. Wang, S. Sugie, and A. Rivenson, “Carcinogenicity of quinoline, 4- and 8-methylquinoline and benzoquinolines in newborn mice and rats,” Food and Chemical Toxicology, vol. 26, no. 7, pp. 625–629, 1988. View at Publisher · View at Google Scholar · View at Scopus
  15. U.S. EPA, “Toxicilogical review of quinoline (CAS no. 91-22-5),” Tech. Rep. EPA/635/R-01/005, 2001. View at Google Scholar
  16. T. Sliwinski, A. Czechowska, M. Kolodziejczak, J. Jajte, M. Wisniewska-Jarosinska, and J. Blasiak, “Zinc salts differentially modulate DNA damage in normal and cancer cells,” Cell Biology International, vol. 33, no. 4, pp. 542–547, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Y. Y. Fong, K.-M. Lau, K. Huebner, and P. N. Magee, “Induction of esophageal tumors in zinc-deficient rats by single low doses of N-nitrosomethylbenzylamine (NMBA): analysis of cell proliferation, and mutations in H-ras and p53 genes,” Carcinogenesis, vol. 18, no. 8, pp. 1477–1484, 1997. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Y. Y. Fong, J. L. Farber, and P. N. Magee, “Zinc replenishment reduces esophageal cell proliferation and N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumor incidence in zinc-deficient rats,” Carcinogenesis, vol. 19, no. 9, pp. 1591–1596, 1998. View at Publisher · View at Google Scholar · View at Scopus
  19. F. Aqil, I. Ahmad, and Z. Mehmood, “Antioxidant and free radical scavenging properties of twelve traditionally used Indian medicinal plants,” Turkish Journal of Biology, vol. 30, no. 3, pp. 177–183, 2006. View at Google Scholar · View at Scopus
  20. Atlas Medical, “Total & Direct Bilirubin for in-vitro diagnostic , DMSO. Colorimetric,” Unit 4, William James House Cowley Rd, Cambridge, UK, CB4 0WX, Revision A, March 2007.
  21. J. Fehér and G. Lengyel, “Silymarin in the prevention and treatment of liver diseases and primary liver cancer,” Current Pharmaceutical Biotechnology, vol. 13, no. 1, pp. 210–217, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Reigh, H. McMahon, M. Ishizaki et al., “Cytochrome P450 species involved in the metabolism of quinoline,” Carcinogenesis, vol. 17, no. 9, pp. 1989–1996, 1996. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Fevery, “Bilirubin in clinical practice: a review,” Liver International, vol. 28, no. 5, pp. 592–605, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Schachter, “Nature of the glucuronide in direct-reacting bilirubin,” Science, vol. 126, no. 3272, pp. 507–508, 1957. View at Google Scholar · View at Scopus
  25. M. Muraca, J. Fevery, and N. Blanckaert, “Analytic aspects and clinical interpretation of serum bilirubins,” Seminars in Liver Disease, vol. 8, no. 2, pp. 137–147, 1988. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Hollstein, R. Talcott, and E. Wei, “Quinoline: conversion to a mutagen by human and rodent liver,” Journal of the National Cancer Institute, vol. 60, no. 2, pp. 405–410, 1978. View at Google Scholar · View at Scopus
  27. U.S. Environmental Protection Agency, Toxicological Review of Quinoline, U.S. Environmental Protection Agency, Washington, DC, USA, 2001.
  28. D. A. Cowan, L. A. Damani, and J. W. Gorrod, “Metabolic N-oxidation of 3-substituted pyridines: identification of products by mass spectrometry,” Biomedical Mass Spectrometry, vol. 5, no. 9, pp. 551–556, 1978. View at Publisher · View at Google Scholar · View at Scopus
  29. C.-C. Lin, D.-E. Shieh, and M.-H. Yen, “Hepatoprotective effect of the fractions of Ban-zhi-lian on experimental liver injuries in rats,” Journal of Ethnopharmacology, vol. 56, no. 3, pp. 193–200, 1997. View at Publisher · View at Google Scholar · View at Scopus
  30. F. A. Kadir, F. Othman, M. A. Abdulla, F. Hussan, and P. Hassandarvish, “Effect of Tinospora crispa on thioacetamide-induced liver cirrhosis in rats,” Indian Journal of Pharmacology, vol. 43, no. 1, pp. 64–68, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. P. Chavalittumrong, A. Attawish, A. Chuthaputti, and P. Chuntapet, “Toxicological study of crude extract of Tinospora crispa Mier ex,” Thai Journal of Pharmaceutical Sciences, vol. 21, pp. 199–210, 1997. View at Google Scholar
  32. P. I. Oteiza, M. S. Clegg, M. P. Zago, and C. L. Keen, “Zinc deficiency induces oxidative stress and AP-1 activation in 3T3 cells,” Free Radical Biology and Medicine, vol. 28, no. 7, pp. 1091–1099, 2000. View at Publisher · View at Google Scholar · View at Scopus
  33. D. A. Wiseman, S. M. Wells, M. Hubbard, J. E. Welker, and S. M. Black, “Alterations in zinc homeostasis underlie endothelial cell death induced by oxidative stress from acute exposure to hydrogen peroxide,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 292, no. 1, pp. L165–L177, 2007. View at Publisher · View at Google Scholar · View at Scopus