Advances in Toxicology

Research Article

Evaluating Systemic Toxicity in Rabbits after Acute Ocular Exposure to Irritant Chemicals

Table 1

In vivo scoring of rabbit eyes, after exposure to ocular irritant chemicals (acute) at the end of 72 h. CPC: cetyl pyridinium chloride, SS: sodium salicylate, IMI: imidazole, ACT: acetaminophen, and NIC: nicotinamide. All values are mean ± SD, .
 ControlCPCSSIMIACTNIC
Cornea      
 Degree of opacity0 ± 00 ± 01 ± 0.570 ± 00 ± 00 ± 0
 Area of cornea0 ± 03 ± 0.572 ± 02 ± 02 ± 02 ± 0
Iris0 ± 02 ± 02 ± 01 ± 02 ± 02 ± 0
Conjunctiva      
 Redness0 ± 03 ± 03 ± 01 ± 02 ± 02 ± 0
 Chemosis0 ± 02 ± 02 ± 02 ± 02 ± 02 ± 0
 Discharge0 ± 02 ± 0.572 ± 02 ± 0.571 ± 02 ± 0
0: normal, 1: slight, 2: moderate, and 3: severe.