Table of Contents
Advances in Toxicology
Volume 2014, Article ID 641813, 7 pages
http://dx.doi.org/10.1155/2014/641813
Research Article

Indium Titanium Oxide Nanoparticles Induced Hepatic Damage: Hepatoprotective Role of Novel 2-Imino-4-methyl-1, 2-Dihydropyrimido [5, 4C] Quinoline-5(6H)-one

1Department of Biotechnology, Sree Narayana Guru College, Coimbatore, Tamil Nadu 641105, India
2Nanotechnology Research Lab, Kongunadu Arts and Science College, Coimbatore, Tamil Nadu 641029, India
3Department of Chemistry, Bharathiar University, Coimbatore, Tamil Nadu 641046, India
4Unit of Toxicology, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu 641046, India
5Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
6Department of Biotechnology, Dr.N.G.P. Arts and Science College, Coimbatore, Tamil Nadu 641048, India
7Nanotechnology Research Laboratory, Department of Physics, Kongunadu Arts and Science College, G N Mills Post, Coimbatore, Tamil Nadu 641029, India

Received 2 August 2014; Revised 18 November 2014; Accepted 19 November 2014; Published 9 December 2014

Academic Editor: Kanji Yamasaki

Copyright © 2014 Dinesh Bheeman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Protective role of 2-imino-4-methyl-1, 2-dihydropyrimido [5, 4C] quinoline-5(6H)-one (IMDHPQ) in indium titanium oxide nanoparticles (InTiO NPs) induced hepatotoxicity was analyzed. InTiO NPs were synthesized and given orally to albino rats to assess their hepatotoxicity. NPs mediated oxidative stress and liver tissue pathology were analyzed. Altered antioxidants (GSH, GPx, and catalase) and, biochemical (SGOT, SGPT, ALP, total protein, and total bilirubin) and histopathological changes were observed due to the oxidative stress caused by InTiO NPs. Varying effects of IMDHPQ on each parameter were observed in the present study. The altered parameters of InTiO NPs exposed rats might be due to the oxidative stress caused by NPs and hepatoprotective or ameliorative efficacy of quinoline compound IMDHPQ on signaling and molecular mechanism needs further study.