Chemical Exposure Generates DNA Copy Number Variants and Impacts Gene Expression

Table 2

CNVs generated by EMS exposure.

Experiment	Concentration (mM)	Chromosome	Start (bp)	End (bp)	Length (kb)	Segmentation mean	Overlap with CNVEs^a
1	0.5	4	34804051	35101102	297.1	0.092	No
1	0.5	8	12592572	13822847	1230.3	−0.088	Yes
1	0.5	9	50187567	50303563	116.0	0.248	No
1	0.5	14	16605821	16732619	126.8	0.276	Yes
1	0.5	24	35425802	35674998	249.2	−0.173	No
1	2	4	22583174	22620167	37.0	−0.792	No
1	2	5	32488684	32820694	332.0	−0.222	No
1	2	5	64239559	64293196	53.6	−0.391	Yes
1	2	6	49556168	50808094	1251.9	−0.199	No
1	2	7	48895436	48948526	53.1	0.583	Yes
1	2	8	32921651	33404812	483.2	−0.321	No
1	2	9	50190782	50306820	116.0	0.445	No
1	2	13	14841216	14864686	23.5	0.705	No
1	2	13	40036069	40492860	456.8	0.151	Yes
1	2	14	16612394	16785422	173.0	0.361	Yes
1	2	16	17135247	18061907	926.7	0.157	No
1	2	18	31915173	33340460	1425.3	−0.235	Yes
1	2	20	8220598	8240372	19.8	0.799	No
1	2	20	16618414	16980789	362.4	0.196	No
1	2	21	8967733	9185499	217.8	0.244	Yes
1	2	21	21053248	21398259	345.0	−0.228	No
1	2	25	31027622	31064013	36.4	−0.579	No
1	5	14	16609009	16769181	160.2	0.282	Yes
2	0.5	4	22586693	22620167	33.5	−0.739	No
2	0.5	5	32662667	32817496	154.8	−0.441	No
2	0.5	7	87	418056	418.0	−0.182	Yes
2	0.5	8	12566432	13625424	1059.0	−0.138	No
2	0.5	13	51315349	51444199	128.9	0.363	No
2	0.5	14	27806152	34875942	7069.8	−0.079	Yes
2	0.5	18	31506143	31908755	402.6	0.117	No
2	0.5	18	43478909	43530599	51.7	−0.521	No
2	0.5	19	8399336	10004277	1604.9	−0.109	No
2	0.5	24	35472028	35709297	237.3	−0.231	No
2	5	4	22586693	22624474	37.8	−0.905	No
2	5	5	32481902	32817496	335.6	−0.398	No
2	5	5	37581072	38022638	441.6	−0.226	No
2	5	5	64165549	65694964	1529.4	−0.139	Yes
2	5	6	49600941	50828098	1227.2	−0.268	No
2	5	7	87	355049	355.0	−0.285	Yes
2	5	8	22262700	23108696	846.0	−0.227	Yes
2	5	13	51328104	51486986	158.9	0.482	No
2	5	14	31449275	33739196	2289.9	−0.159	Yes
2	5	18	27977948	31396054	3418.1	−0.161	Yes
2	5	18	31911993	33198929	1286.9	−0.260	Yes

CNVEs as called in AB strain zebrafish in [22].