The Relationship of HLA Class I and II Alleles and Haplotypes with Autism: A Case Control Study
Table 3
Frequency of HLA haplotypes in autistic children and controls.
Haplotypes
Patients
Controls
Statistical analysis
HLA class I
HLA class II
no./35 (%)
no./100 (%)
OR (95% CI)
A*01
B*07
DRB1*0701
DQB1*0602
5 (14.3)
4 (0.50)
41.9 (4.9–903.7)
0.001
A*01
B*08
DRB1*0301
DQB1*0201
1 (2.85)
4 (0.50)
6.18 (0.4–179.7)
0.32
A*02
B*08
DRB1*0301
DQB1*0201
1 (2.85)
12 (1.5)
2.02 (0.22–15.8)
0.80
A*02
B*14
DRB1*0102
DQB1*0507
2 (5.71)
7 (0.88)
6.5 (0.9–54.4)
0.058
A*02
B*15
DRB1*1104
DQB1*0301
2 (5.71)
8 (1.00)
6.5 (0.9–54.4)
0.058
A*02
B*18
DRB1*0701
DQB1*0202/06
2 (5.71)
7 (0.88)
6.5 (0.9–54.4)
0.058
A*02
B*35
DRB1*0403
DQB1*0302
1 (2.85)
17 (2.13)
1.5 (0.18–10.2)
1.00
A*02
B*40
DRB1*1101
DQB1*0301
1 (2.85)
5 (0.63)
6.1 (0.41–178.7)
0.32
A*02
B*41
DRB1*1301
DQB1*0603
2 (5.71)
11 (1.38)
4.3 (0.7–26.1)
0.12
A*02
B*44
DRB1*1104
DQB1*0301
1 (2.85)
4 (0.50)
6.1 (0.4–179.7)
0.32
A*02
B*50
DRB1*1102
DQB1*0501
1 (2.85)
42 (5.26)
0.51 (0.07–2.62)
0.59
A*23
B*50
DRB1*1501
DQB1*0603
1(2.85)
18 (2.26)
1.18 (0.15–7.4)
1.00
A*26
B*51
DRB1*1407
DQB1*0503
2 (5.71)
6 (0.75)
6.5 (0.9–54.4)
0.058
A*31
B*51
DRB1*0103
DQB1*0302
4 (11.42)
22 (2.76)
4.8 (1.35–17.5)
0.01
A*32
B*51
DRB1*1302
DQB1*0604
1 (2.85)
11 (1.38)
2.02 (0.22–15.8)
0.80
A*68
B*58
DRB1*1201
DQB1*0501
1 (2.85)
5 (0.63)
3.06 (0.29–32.08)
0.57
AF: allele frequency; OR: odds ratio; 95% CI: confidence interval; NS: not significant. The bold font in table refers to significant association of alleles and haplotype with autism.
