Improving Outcome in Infantile Autism with Folate Receptor Autoimmunity and Nutritional Derangements: A Self-Controlled Trial

Table 1

The treatment protocol for the self-controlled treatment trial based upon abnormal biochemical findings and FRα autoantibodies.

Abnormal biomarker	Daily oral supplement dosage
Zinc deficiency	0.15-0.25 mg/kg zinc-sulfate
Selenium deficiency	3-5 µg/kg sodium-selenite
Manganese deficiency	5-10 mg/kg Vitamin C, 20 IU/kg Vitamine E, with 1 coffespoon Soya oil at night.
Manganese excess	idem
Heavy metal excess (Cu, Al, Hg, Pb)	idem
Raised copper/zinc ratio	idem
Bèta-carotene excess	idem; limit foods rich in bèta-carotene
Vitamin A deficiency	600-1500 µg
Vitamin D (25-hydroxy-D)	10 µg or 400 IU
Vitamin C deficiency	5-10 mg/kg Vitamine C (maximal 500mg)
Ubiquinon-10 deficiency	2 mg/kg co-enzyme Q10
Vitamin E deficiency	20 IU/kg
Gamma-Tocopherole deficiency	1 coffeespoon soya, corn or sesame oil
Bèta-carotene deficiency	Consume tomato or carot juices
Serum folate deficiency	0.5 mg/kg folinic acid
RBC folate deficiency	0.5 mg/kg folinic acid
Apolipoproteine B deficiency	Supplement vitamins A D E, and vitamine K in case of secondary coagulation disorder
FR-alpha antibodies	Start with 0.5-1 mg/kg folinic acid daily;
	Increase to 2 mg/kg daily without a clinical response after six months. Maximum daily dose 50 mg.