Oxidative Stress, Folate Receptor Autoimmunity, and CSF Findings in Severe Infantile Autism
Table 1
Case-control study comparing oxidative stress parameters (mean ± SD) between autistic children and age-matched healthy controls.
Parameter
Autism
Controls
Reference range for controls
Statistics ( value)
Number
38
24
Age (years)
7.25 ± 3.9
8.7 ± 3.2
4.4–16
Comet assay (% oxidized DNA)
24 ± 9
14.9 ± 3.9
10.2–21.5
Lipid peroxides (μM)
673 ± 339
609 ± 219
183–1095
Oxidized LDL (ng/ml)
1465 ± 1377
1257 ± 1111
78–3490
Antibodies against ox-LDL (IU/L)
747 ± 428
568 ± 419
82–1200
Paroxonase (μM/L)
147 ± 115
137 ± 75
3–282
Copper (mg/L)
1.13 ± 0.26
0.99 ± 0.25
0.57–1.78
Manganese (μg/L)
10.1 ± 2.58
10 ± 1.86
6.98–15.24
Selenium (μg/L)
77.4 ± 21.2
77.21 ± 11.53
50.5–98.5
Zinc (mg/L)
0.84 ± 0.16
0.84 ± 0.11
0.59–1.02
Ratio copper/zinc
1.34 ± 0.35
1.17 ± 0.23
0.74–1.79
Ceruloplasmin (g/L)
0.31 ± 0.06
0.28 ± 0.05
0.18–0.39
Vitamine C (μg/ml)
11.5 ± 4.82
14 ± 2.9
5.14–19.49
Ubichinon Q10 (mg/L)
0.68 ± 0.25
0.64 ± 0.17
0.35–1.06
Vitamine E (mg/L)
10.08 ± 2.17
10.7 ± 2.4
6.4–16.38
Gamma-tocopherol (mg/L)
0.63 ± 0.41
0.70 ± 0.26
0.29–1.28
Beta-carotene (mg/L)
0.3 ± 0.29
0.39 ± 0.25
0.05–0.99
Thiol proteins (μM/L)
402 ± 47
363 ± 67
203–436
Total glutathione (μM/L)
851 ± 204
811 ± 141
615–1162
Oxidized glutathione (μM/L)
1.24 ± 1.87
1.39 ± 2
0.53–9.37
Glutathione peroxidase (IU/g Hb)
42.2 ± 16.5
40.25 ± 8.4
25–59
Superoxide dismutase (IU/g Hb)
1646 ± 319
1432 ± 168
1057–1772
The reference range for controls shows the upper and lower boundary limits for healthy controls. The determined values using the unpaired student t-test can be found in the last column.
