Oxidative Stress, Folate Receptor Autoimmunity, and CSF Findings in Severe Infantile Autism
Table 4
CARS and CSF findings at baseline and following antioxidant supplementation during 8 months (patients 1 and 2) and during 2 years (patient 3) among three children with severe infantile autism.
Patient
Age (yr)
5HIAA
HVA
Ratio
MTHF
Neo
Bio
Oxidative stress
CARS
(1) Baseline
3½
104↓
566
5.4↑
117
8.6
23
Lipid peroxides↑
42
Treatment
4½
160
436
2.7
100
18
37
34
(2) Baseline
4½
81↓
338
4.2↑
95
35
19
Lipid peroxides↑
45.5
Treatment
5.3
136
495
3.6↑
113
25
61
Lipid peroxides normal
43.5
(3) Baseline
17
25.6↓
92↓
3.6↑
82.7
9.5
10.7
Ox DNA↑, Trp↓
41
Treatment
19½
80
258
3.2
49
10
7↓
References (median and range)
2–4 yr
202 (105–299)
603 (211–871)
63–111
9–30
10–30
5–10 yr
133 (88–178)
523 (144–801)
41–117
9–20
10–30
>16 yr
103 (66–141)
261 (115–488)
41–117
9–20
10–30
Ratio stands for the HVA/5HIAA ratio with a normal range 1.5–3.5. The sign ↑ denotes elevated value, and the sign ↓ denotes diminished value.
