|
| Reference | Habituation | Duration of each test | Coding methods | Sociability measurement | Index used? | Social behavior comparison | Outcome |
|
| Dufour-Rainfray et al. [9] | Not specified | 3 min (only-2-stranger test) | Not specified | Time spent in each compartment and number of crosses from one compartment to another | No | Time spent in each chamber across groups | VPA spent more time in empty chamber. VPA had increased number of chamber crosses |
| Gantal et al. [10] | Full apparatus for 2 days before testing | 10 min (only one stranger) | TopScan | Time spent sniffing and sniffing events | SPI = S1/(S1 + Obj) | Social preference index | VPA had reduced social preference |
| Kim et al. [12] | Center only for 5 min | 10 min | EthoVision | Time spent in each chamber and approach sniffing time | SPI = S1/E
SPI = S2
/S1 | Time spent in each chamber compared across groups | VPA mice spent more time in the empty chamber and less time in stranger chamber. VPA spent more time with familiar mouse and less time with stranger |
| Bambini-Junior et al. [13] | Center only for 5 min | 10 min | Manual real-time by two observers | Time spent in each chamber and time spent sniffing | SI = (S1 − Obj)/(S1 + Obj)SNI = (S2 − S1)/(S2 + S1) | Time with novel object and time with stranger rat | VPA spent equal time with novel object and stranger rat. VPA did not show novelty preference, but control preferred novel over familiar |
| Baronio et al. [15] | 5 min (location not specified) | 10 min | Manual real-time observation | Time spent in chamber and undefined time “spent exploring” | SI-(S1 − Obj)/(S1 + Obj)SNI = (S2 − F)/(S2 + F) | Time with stranger mouse and time with novel object | VPA spent equal time with novel object and stranger mouse. VPA spent equal time exploring novel and familiar mice, but control preferred novel over familiar |
| Kang and Kim [14] | Center only 10 min, full apparatus 10 min | 10 min | EthoVision | Sniffing time and chamber time | PI = (S1 − E)/(S1 + E)PI = (S2 − S1)/(S1 + S2) | Time with stranger mouse and time with empty cage | VPA spent more time sniffing stranger than empty, but not as large of a difference as control. No social novelty preferences for VPA or control |
| Campolongo et al. [16] | 5 minutes to full apparatus with cylinders | 10 min (only one stranger) | Manual from recording | Sniffing time | No | Compared stranger mouse sniffing time across groups and to novel object | VPA spent less time sniffing stranger mouse than saline |
| Bronzuoli et al. [17] | Full apparatus 10 min | 10 min (only one stranger) | Noldus Observer software | Sniffing time | No | Compared stranger sniffing time across groups | VPA spent less time sniffing stranger mouse than saline |
| Sgritta et al. [18] | Full apparatus 10 min | 10 min | ANY maze, manual from recording (blind) | Sniffing time plus time climbing on cup | No | Time sniffing novel object and time sniffing stranger mouse | VPA spent same time sniffing stranger and object. VPA and control spent more time sniffing stranger mouse 2 than familiar |
|
