Review Article
A Need for Consistency in Behavioral Phenotyping for ASD: Analysis of the Valproic Acid Model
Table 4
Repetitive behavior in open environments.
| Reference | Apparatus | Pretest habituation | Duration | Coding methods | Behaviors analyzed | Outcome |
| Gandal et al. [10] | Cage without bedding | 20 min to new cage | 10 min | Manual real-time (blind) | Time spent grooming | VPA increased total grooming time | Kim et al. [12] | Typical cage | 10 min to new cage | 10 min | Real-time 2 meters from cage | Grooming and digging | VPA increased digging. No difference for grooming | Kang and Kim [14] | Fresh bedded home cage in novel environment | 72-hour isolation | 10 min | Manual from recording | Grooming time, jumping bouts, digging | VPA increased grooming time and jumping bouts | Kang and Kim [14] | 48-hour movements in familiar environment | 48-hour isolation | 48 hours | Vibration sensitive plate LABORAS cage | Distance moved, grooming time, total rearing time | No difference between VPA and saline | Campolongo et al. [16] | Clear plexiglass cylinder | 1-hour habituation for 2 days before testing | 10 min | Manual from recording, condition blind | Grooming of all body regions | Effect of VPA treatment on grooming |
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