A Need for Consistency in Behavioral Phenotyping for ASD: Analysis of the Valproic Acid Model

Table 6

Open field.

Reference	Pretest habituation	Duration (minutes)	Coding methods	Behaviors analyzed	Center area	Outcome
Gandal et al. [10]	—	10	TopScan	Total distance traveled and time spent in the center of field	19% of total area	VPA spent less time in the center
Kataoka et al. [5]	—	90	Acti-track	Distance traveled, number of rearings, and number of entries into the center	Center undefined	VPA male and female decreased distance traveled, rearings, and entries into the center
Chen et al. [11]	—	15	EthoVision	Present time in central zone and total distance moved	25% of total area	VPA spent less time in the center
Kim et al. [12]	5 min	20	EthoVision	Total distance and velocity	—	VPA had increased motor activity and velocity
Campolongo et al. [16]	—	30	ANY-maze and manual (blind)	Total distance traveled, time spent in the center, time grooming, and number of rearings	26% of total area	No difference in the center time for VPA and saline. Treatment effect on grooming time
Sgritta et al. [18]	—	10	Any-maze	Distance traveled, speed, and time spent in the center	25% of total area	Results not reported for VPA