A Need for Consistency in Behavioral Phenotyping for ASD: Analysis of the Valproic Acid Model

Table 7

Elevated plus maze.

Reference	Behaviors analyzed	Coding methods	Duration (min)	Outcome
Markram et al. [8]	Time spent in open and closed arms, total distance, and total velocity	Not specified	5	VPA spent less time in open arms than control. Distance and velocity were the same
Kataoka et al. [5]	Time spent and entries into open and closed arms	Manually scored from video (blind)	5	VPA males and females spent less time in open arms and more time in closed arms compared to control
Chen et al. [11]	Percent time spent in each arm and total distance	EthoVision	5	VPA males spent less time in open arms compared to control
Kim et al. [12]	Relative stay time ratio (open/closed)	EthoVision	5	VPA spent more time in open arms
Campolongo et al. [16]	Time spent in arms, distance traveled in arms, rearing, grooming, and head dips	ANY-maze for locomotion, manual for behavioral (blind)	5	VPA and saline spent same amount of time in open and closed arms