Table of Contents
Advances in Vascular Medicine
Volume 2014, Article ID 653482, 7 pages
Review Article

Vascular Functions and Brain Integrity in Midlife: Effects of Obesity and Metabolic Syndrome

1Departments of Psychology, The University of Texas at Austin, 108 E. Dean Keeton, Stop A8000, Austin, TX 78712, USA
2Imaging Research Center, The University of Texas at Austin, 100 East 24th Street, Stop R9975, Austin, TX 78712, USA

Received 3 February 2014; Revised 25 May 2014; Accepted 4 June 2014; Published 24 June 2014

Academic Editor: David Tanne

Copyright © 2014 Andreana P. Haley. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Intact cognitive function is the best predictor of quality of life and functional ability in older age. Thus, preventing cognitive decline is central to any effort to guarantee successful aging for our growing population of elderly. The purpose of the work discussed in this outlook paper is to bridge knowledge from basic and clinical neuroscience with the aim of improving how we understand, predict, and treat age- and disease-related cognitive impairment. Over the past six years, our research team has focused on intermediate neuroimaging phenotypes of brain vulnerability in midlife and isolating the underlying physiological mechanisms. The ultimate goal of this work was to pave the road for the development of early interventions to enhance cognitive function and preserve brain integrity throughout the lifespan.