Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors

Table 2

Y-chromosome encoded MiHA.

MiHA	Restriction	Identification	Clinical trials	Protein	Tissue distribution	Presence on cells
A1/HY	HLA-A*01	Pierce et al. 1999 [30]	—	USP9Y	Broad	Hematopoietic cells, fibroblasts
A2/HY	HLA-A*02	Meadows et al. 1997 [31]	Goulmy et al. 1996 [15]	SMCY	Broad	Hematopoietic cells, fibroblasts
A33/HY	HLA-A*33	Torikai et al. 2004 [32]	—	TMSB4Y	Broad	Hematopoietic cells
B7/HY	HLA-B*07	Wang et al. 1995 [33]	—	KDMSD	Broad	Hematopoietic cells
B8/HY	HLA-B*08	Warren et al. 2000 [34]	—	UTY	Restricted	Hematopoietic cells
B52/HY	HLA-B*52	Ivanov et al. 2005; [35]	—	RPS4Y1	Restricted	Leukocytes, PHA blasts, EBV-BLCLs, B cells, breast carcinoma, hepatocellular carcinoma, colon adenocarcinoma, AML, ALL multiple myeloma
B60/HY	HLA-B*60	Vogt et al. 2000 [36]	—	UTY	Broad	Hematopoietic cells, fibroblasts
DRB1*1501/HY	HLA-DRB1*15	Zorn et al. 2004; [37]	—	DDX3Y (DBY)	Broad	Hematopoietic cells, fibroblasts
DRB3*0301/HY	HLA-DRB3*0301	Spierings et al.2003 [38]	—	RPS4Y1	Broad	Hematopoietic cells, fibroblasts
DQ5/HY	HLA-DQB1*05	Vogt et al. 2002 [39]	—	DDX3Y (DBY)	Broad	Hematopoietic cells, fibroblasts

Abbreviations: HUVE: human umbilical vein epithelium, PTE: proximal tubular epithelium, EBV-BLCL: Epstein Barr virus transformed B-lymphoblastoid cell lines, and PHA: phytohemagglutinine.
Data in Tables 1 and 2 are based on dbMinor database and materials presented during Minor Histocompatibility Workshop 2005, Leiden University Medical Center; Eric Spierings: minor H antigens: targets for tumor therapy—lecture at the conference “Immunogenetics in hematology and stem cell transplantation”, Wroclaw 09.02.2006 and [8].