Bone Marrow Research / 2012 / Article / Tab 7 / Clinical Study
Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors Table 7 Influence of MiHA mismatches on allo-HCT outcomes.
Analyzed outcome Analyzed MiHA Direction of mismatch Presence of mismatch
Probability (95% CI)
Overall survival Autosomal GVH Yes 15 2 yrs: 0.9286 (0.5278–0.9892) 0.045 4 yrs: 0.7619 (0.3481–0.9130) No 47 2 yrs: 0.6046 (0.4329–0.7243) 4 yrs: 0.5265 (0.3511–0.6545) HY GVH Yes 12 2 years: 0.4167 (0.0590–0.6384) 0.011 3 years: 0.3333 (0.0054–0.5532) No 50 2 years: 0.7546 (0.5986–0.8500) 3 years: 0.6822 (0.5152–0.7916) Disease-free survival HY GVH Yes 12 2 years: 0.4167 (0.0590–0.6384) 0.050 3 years: 0.3333 (0.0054–0.5532) No 50 2 years: 0.6526 (0.4896–0.7635) 3 years: 0.6526 (0.4896–0.7635) Serious aGVHD HY GVH Yes 12 0.1667 (0.0470–0.5906) 0.037 No 50 0.0200 (0.0029–0.1392) Extensive cGVHD HY GVH Yes 11 0.3636 (0.1664–0.7947) 0.017 No 43 0.1395 (0.0664–0.2931) Relapse Autosomal HVG Yes 12 0 (0-0) 0.032 No 50 0.2836 (0.1818–0.4423) Restricted HVG Yes 13 0 (0-0) 0.028 No 49 0.2879 (0.1849-0.4482)