Hematopoietic Stem Cell Development, Niches, and Signaling Pathways

Figure 5

c-Mpl/TPO signaling pathway. TPO signals to its receptor, c-Mpl, and induces the downstream signaling cascades: STATs, PI3K, MAPKs, and extracellular signal regulated kinases-1 and -2 (modified from [14, 15]).