Comparison of possible downstream effects of miR-15a/16-1 during (a) healthy cells and (b) CLL cells. In healthy cells, high miR-15a/16-1 expression results in appropriate silencing of targets BCL2, WT1, and cell cycle factors. In CLL, low miR-15a/16-1 expression results in uninhibited expression of BCL2, WT1, and the cell cycle factors resulting in evasion of apoptosis and uncontrolled cell cycle progression.
