The dual oncogenic and tumour suppressor nature of miR-17-92. The transcription factor c-myb induces expression of both miR-17-92 and E2F1. MiR-17-92 can subsequently act both as a tumour suppressor gene through inhibition of E2F1 or as an oncogene via the targeted silencing of tumour suppressor genes such as PTEN and Bim.
