Research Article
Validation of the EBMT Risk Score for South Brazilian Patients Submitted to Allogeneic Hematopoietic Stem Cell Transplantation
Table 2
Impact of pretransplant risk factors on overall survival.
| | Risk factors | AML | ALL | CML | AA | Total |
| | Age class | | <20 | 1 | 1 | 1 | 1 | 1 | | 20–40 | 3.4 (1.0–11.7) | 1.3 (0.6–2.8) | 0.9 (0.3–3.0) | 1.7 (0.7–4.5) | 1.4 (0.9–2.2) | | >40 | 3.8 (1.1–13.7) | 1.4 (0.5–3.9) | 1.1 (0.3–3.9) | 1.1 (0.2–5.3) | 1.4 (0.9–2.2) |
| | Disease stage | | Early | 1 | 1 | 1 | 1 | 1 | | Intermediate | 2.1 (0.8–5.4) | 1.4 (0.6–3.0) | 1.9 (0.9–4.0) | — | 1.5 (1.0–2.2) | | Advanced | 5.1 (2.1–12.8) | 2.4 (0.9–6.3) | 2.1 (0.6–6.8) | — | 2.0 (1.3–3.1) |
| | Time interval | | <12 months | 1 | 1 | 1 | 1 | 1 | | >12 months | 1.8 (0.8–3.8) | 0.8 (0.4–1.8) | 1.7 (0.7–4.3) | 1.4 (0.5–3.5) | 1.5 (1.1–2.2) |
| | Donor type | | HLA | 1 | 1 | 1 | 1 | 1 | | Other | 3.0 (1.3–7.1) | 1.6 (0.8–3.3) | 3.6 (1.5–8.6) | 1.7 (0.6–5.2) | 2.4 (1.6–3.6) |
| | Gender combination | | Other | 1 | 1 | 1 | 1 | 1 | | DF/RM | 2.4 (1.2–5.1) | 1.9 (0.9–4.0) | 0.7 (0.3–1.4) | 0.8 (0.3–2.3) | 1.1 (0.8–1.7) |
| | ROC curve | | AUC | 0.802 | 0.743 | 0.631 | 0.590 | 0.667 |
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AML: acute myeloid leukemia; ALL: acute lymphoblastic leukemia; CML: chronic myeloid leukemia; HLA IS: human leukocyte antigen identical sibling; DF/RM: donor female/recipient male; ROC AUC: receiver operating characteristics area under the curve.
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