Bone Marrow Research / 2013 / Article / Tab 2

Clinical Study

Day 100 Peripheral Blood Absolute Lymphocyte/Monocyte Ratio and Survival in Classical Hodgkin's Lymphoma Postautologous Peripheral Blood Hematopoietic Stem Cell Transplantation

Table 2

Baseline characteristics based on Day 100 ALC/AMC.

CharacteristicsDay 100 ALC/AMC ≥ 1.3
( = 99)
Day 100 ALC/AMC < 1.3
( = 32)
value

At diagnosis
Age, years, median (range)33 (18–68)32 (18–56)0.8
Gender<0.008
 Male44 (44%)23 (72%)
 Female55 (56%)9 (28%)
Albumin (g/dL)4 (2–4.6)3.9 (2.2–4.6)<0.008
ALC × 109/L1.7 (0.2–2.9)0.5 (0.2–2.7)<0.0001
Hemoglobin (g/dL)12.6 (7.7–16.2)11.1 (8.1–15.4)0.07
Mediastinal disease<0.004
 ≥10 cm10 (10%)4 (34%)
 <10 cm89 (90%)21 (66%)
Stage0.9
 I5 (5%)1 (3%)
 II42 (43%)14 (44%)
 III26 (26%)9 (28%)
 IV26 (26%)8 (25%)
Stage0.9
 Limited46 (47%)15 (47%)
 Advanced52 (53%)17 (53%)
WBC × 109/L8.0 (1.4–22.2)12.1 (2.3–20.1)<0.0003
IPS risk factors
Age, years0.9
 ≤4582 (83%)27 (84%)
 >4517 (17%)5 (16%)
Albumin (g/dL)
( = 127)
<0.002
 ≥468 (71%)12 (39%)
 <428 (29%)19 (61%)
ALC × 109/L<0.0001
 ≥0.692 (93%)14 (44%)
 <0.67 (7%)18 (56%)
Hemoglobin (g/dL)0.06
 >10.581 (82%)21 (66%)
 ≤10.518 (18%)11 (34%)
Male44 (44%)23 (72%)<0.008
Stage 426 (26%)8 (25%)0.9
WBC × 109/L<0.001
 >159 (9%)11 (34%)
 ≤1590 (91%)21 (66%)
IPS score<0.01
 026 (26%)4 (13%)
 133 (34%)8 (25%)
 221 (21%)6 (18%)
 310 (10%)3 (9%)
 46 (6%)4 (13%)
 53 (3%)4 (13%)
 60 (0%)3 (9%)
IPS index<0.009
 ≥319 (19%)14 (44%)
 <380 (81%)18 (56%)
At transplant
Infused CD34+ stem cells × 106/kg5.3 (2.6–15.8)4.5 (2.1–13.2)0.1
Pretransplant response0.06
 CR27 (27%)3 (9%)
 PR72 (72%)29 (91%)
ALC × 109/L0.78 (0.1–3.67)0.39 (0.18–3.19)<0.0001
ALC × 109/L<0.0001
 ≥0.580 (81%)10 (31%)
 <0.519 (19%)22 (69%)
At day 100 post-APBHSCT
Age, years36 (18–66)34.5 (19–58)0.9
Hemoglobin (g/dL)12.1 (8.5–16.7)11.4 (7.3–14.1)0.4
WBC × 109/L4.6 (2.2–9.4)3.7 (1.5–14.3)0.1
ANC × 109/L2.6 (0.8–6.9)2.4 (1.0–10.0)0.9
ALC × 109/L1.33 (0.51–4.61)0.39 (0.15–3.94)<0.0001
AMC × 109/L0.43 (0.15–1.58)0.63 (0.29–4.02)<0.0001
Plts × 109/L172 (121–373)163 (177–334)0.2

Abbreviations: ALC: absolute lymphocyte count; ANC: absolute neutrophil count; AMC: absolute monocyte count; CR: complete remission; IPS: international prognostic score; PR: partial response; Plts: platelets; and WBC: white blood cell count.