Bone Marrow Vascular Niche: Home for Hematopoietic Stem Cells

Figure 2

Vascular niche plays a key role in hematopoiesis. Vascular niche is termed as an alternative niche compared to osteoblastic niche. Through the interaction between the HSCs and ECs, HSCs operate the process of self-renewal and differentiation. The hematopoietic progenitor cells derived from HSCs quiescent in osteoblastic niche penetrate the ECs to reside in vascular niche and then differentiate into different kinds of blood cells, entering the circulation system.