The RAG Model: A New Paradigm for Genetic Risk Stratification in Multiple Myeloma

Table 3

RAG model categories.

RAG category	Initiation/primary event	Progression/secondary event
Hyperdiploidy; (Trisomies—1, 3, 5, 7, 9, 11, 15, 19, 21)	✓
t(4;14)	✓
t(6;14)	✓
t(11;14)	✓
t(14;16)	✓
t(14;20)	✓
+1q		✓
Del(1p)		✓
Del(11q)		✓
Del(12p)		✓
Del(13/13q)		✓
Del(14q)		✓
Del(16q)		✓
Del(17p)		✓
Secondary t(8;14)		✓
Bone disease		✓
Proliferation		✓
Apoptosis and NF-B		✓
Differentiation		✓
DNA repair		✓
RNA editing		✓
Epigenetic		✓