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Bone Marrow Research
Volume 2015, Article ID 176526, 6 pages
http://dx.doi.org/10.1155/2015/176526
Research Article

Very Long Term Stability of Mixed Chimerism after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Hematologic Malignancies

1Department of Hemato-Oncology, Hôpital Fribourgeois, 1708 Fribourg, Switzerland
2Division of Hematology, Geneva University Hospital, 1205 Geneva, Switzerland
3Transplantation and Cellular Therapy Unit, Paoli-Calmettes Institute, 13009 Marseille, France
4Division of Hematology, Basel University Hospital, 4056 Basel, Switzerland

Received 2 September 2015; Accepted 22 October 2015

Academic Editor: César O. Freytes

Copyright © 2015 Emmanuel Levrat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. L. Liesveld and P. G. Rothberg, “Mixed chimerism in SCT: conflict or peaceful coexistence?” Bone Marrow Transplantation, vol. 42, no. 5, pp. 297–310, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. J. E. M. Van Leeuwen, M. J. D. Van Tol, A. M. Joosten et al., “Persistence of host-type hematopoiesis after allogeneic bone marrow transplantation for leukemia is significantly related to the recipient's age and/or the conditioning regimen, but it is not associated with an increased risk of relapse,” Blood, vol. 83, no. 10, pp. 3059–3067, 1994. View at Google Scholar · View at Scopus
  3. S. Bretagne, M. Vidaud, M. Kuentz et al., “Mixed blood chimerism in T cell-depleted bone marrow transplant recipients: evaluation using DNA polymorphisms,” Blood, vol. 70, no. 5, pp. 1692–1695, 1987. View at Google Scholar · View at Scopus
  4. M. Park, K. N. Koh, J. J. Seo, and H. J. Im, “Clinical implications of chimerism after allogeneic hematopoietic stem cell transplantation in children with non-malignant diseases,” Korean Journal of Hematology, vol. 46, no. 4, pp. 258–264, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Svenberg, J. Mattsson, O. Ringdén, and M. Uzunel, “Allogeneic hematopoietic SCT in patients with non-malignant diseases, and importance of chimerism,” Bone Marrow Transplantation, vol. 44, no. 11, pp. 757–763, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. B. R. Dey, S. McAfee, C. Colby et al., “Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation,” Biology of Blood and Marrow Transplantation, vol. 9, no. 5, pp. 320–329, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. E. Rettinger, A. M. Willasch, H. Kreyenberg et al., “Preemptive immunotherapy in childhood acute myeloid leukemia for patients showing evidence of mixed chimerism after allogeneic stem cell transplantation,” Blood, vol. 118, no. 20, pp. 5681–5688, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. K. S. Peggs, I. Kayani, N. Edwards et al., “Donor lymphocyte infusions modulate relapse risk in mixed chimeras and induce durable salvage in relapsed patients after T-cell-depleted allogeneic transplantation for Hodgkin's lymphoma,” Journal of Clinical Oncology, vol. 29, no. 8, pp. 971–978, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. I. Frugnoli, B. Cappelli, R. Chiesa et al., “Escalating doses of donor lymphocytes for incipient graft rejection following SCT for thalassemia,” Bone Marrow Transplantation, vol. 45, no. 6, pp. 1047–1051, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Lamba, E. Abella, D. Kukuruga et al., “Mixed hematopoietic chimerism at day 90 following allogenic myeloablative stem cell transplantation is a predictor of relapse and survival,” Leukemia, vol. 18, no. 10, pp. 1681–1686, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Huisman, R. A. de Weger, L. de Vries, M. G. J. Tilanus, and L. F. Verdonck, “Chimerism analysis within 6 months of allogeneic stem cell transplantation predicts relapse in acute myeloid leukemia,” Bone Marrow Transplantation, vol. 39, no. 5, pp. 285–291, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Chalandon, E. Roosnek, B. Mermillod, L. Waelchli, C. Helg, and B. Chapuis, “Can only partial T-cell depletion of the graft before hematopoietic stem cell transplantation mitigate graft-versus-host disease while preserving a graft-versus-leukemia reaction? A prospective phase II study,” Biology of Blood and Marrow Transplantation, vol. 12, no. 1, pp. 102–110, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Roux, C. Helg, B. Chapuis, M. Jeannet, and E. Roosnek, “Evolution of mixed chimerism after allogeneic bone marrow transplantation as determined on granulocytes and mononuclear cells by the polymerase chain reaction,” Blood, vol. 79, no. 10, pp. 2775–2783, 1992. View at Google Scholar · View at Scopus
  14. Y. Chalandon, S. Vischer, C. Helg, B. Chapuis, and E. Roosnek, “Quantitative analysis of chimerism after allogeneic stem cell transplantation by PCR amplification of microsatellite markers and capillary electrophoresis with fluorescence detection: the Geneva experience,” Leukemia, vol. 17, no. 1, pp. 228–231, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Schaap, A. Schattenberg, E. Mensink et al., “Long-term follow-up of persisting mixed chimerism after partially T cell-depleted allogeneic stem cell transplantation,” Leukemia, vol. 16, no. 1, pp. 13–21, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Stikvoort, J. Gertow, M. Sundin, M. Remberger, J. Mattsson, and M. Uhlin, “Chimerism patterns of long-term stable mixed chimeras posthematopoietic stem cell transplantation in patients with nonmalignant diseases: follow-up of long-term stable mixed chimerism patients,” Biology of Blood and Marrow Transplantation, vol. 19, no. 5, pp. 838–844, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Stumph, C. L. Vnencak-Jones, T. Koyama, and H. Frangoul, “Comparison of peripheral blood and bone marrow samples for detection of post transplant mixed chimerism,” Bone Marrow Transplantation, vol. 41, no. 6, pp. 589–590, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. F. Khan, A. Agarwal, and S. Agrawal, “Significance of chimerism in hematopoietic stem cell transplantation: new variations on an old theme,” Bone Marrow Transplantation, vol. 34, no. 1, pp. 1–12, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Koldehoff, N. K. Steckel, M. Hlinka, D. W. Beelen, and A. H. Elmaagacli, “Quantitative analysis of chimerism after allogeneic stem cell transplantation by real-time polymerase chain reaction with single nucleotide polymorphisms, standard tandem repeats, and Y-chromosome-specific sequences,” American Journal of Hematology, vol. 81, no. 10, pp. 735–746, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. X.-Y. Qin, G.-X. Li, Y.-Z. Qin et al., “Quantitative assessment of hematopoietic chimerism by quantitative real-time polymerase chain reaction of sequence polymorphism systems after hematopoietic stem cell transplantation,” Chinese Medical Journal, vol. 124, no. 15, pp. 2301–2308, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Van Besien, A. Dew, S. Lin et al., “Patterns and kinetics of T-cell chimerism after allo transplant with alemtuzumab-based conditioning: mixed chimerism protects from GVHD, but does not portend disease recurrence,” Leukemia and Lymphoma, vol. 50, no. 11, pp. 1809–1817, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Nikolousis, S. Robinson, S. Nagra et al., “Post-transplant T cell chimerism predicts graft versus host disease but not disease relapse in patients undergoing an alemtuzumab based reduced intensity conditioned allogeneic transplant,” Leukemia Research, vol. 37, no. 5, pp. 561–565, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Miura, J. Tanaka, T. Toubai et al., “Analysis of donor-type chimerism in lineage-specific cell populations after allogeneic myeloablative and nonmyeloablative stem cell transplantation,” Bone Marrow Transplantation, vol. 37, no. 9, pp. 837–843, 2006. View at Publisher · View at Google Scholar · View at Scopus