Bone Marrow Research

Biological and Genetic Aspects of Donor-Recipient Matching in HSCT


Publishing date
16 Nov 2012
Status
Published
Submission deadline
29 Jun 2012

Lead Editor

1Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland

2Anthony Nolan Research Institute, London NW3 2QG, UK

3Fondation Jean Dausset, 75010 Paris, France


Biological and Genetic Aspects of Donor-Recipient Matching in HSCT

Description

The genetic diversity at the HLA genes has resulted in the need for high-resolution tissue typing methods to ensure a full match. However, not all DNA changes are relevant for mounting the reactivity against the recipient and host cells. Therefore, we address the questions: (i) what is the functional relevance of an allelic mismatch and (ii) whether this translates into a new structure recognized by immune cells. This will aid us in identifying permissive and nonpermissive mismatches.

Recent publications suggest the association between polymorphisms in genes involved in cell trafficking and those influencing the pace and the regulation of the immune response and the risk of post-HSCT complications. In spite of this, no consistent recommendations have yet been made as to the practical use of this type of immunogenetic evaluation of donor-recipient pairs.

Bearing in mind that the patient should get the best possible donor, independently of a donor location, the international cooperation is mandatory. It is well recognized that the timing of donor acquisition is an important aspect of patient outcome. Therefore, all information on that as well as on the tools available to shorten the process is of practical value.

Independent of HLA matching status, the past history of the donor influences the ability of the transplanted cells to “see” too many or to neglect some epitopes. This raises the risk of alloreactivity in both the host and graft directions, as well as differencing potential to fight relapsing disease (graft versus leukemia reaction) or opportunistic infections. Such biological evaluations may focus on areas such as the pace of lymphocyte repopulation, tissue pathology, infectious complications, and relapse.

We are inviting all experts in this field to provide their opinions and data (patient outcome and biological/experimental) in any of these areas. Potential topics include, but are not limited to:

  • HLA diversity recognition and its role in optimal matching in HSCT
  • Specific alleles and mutations in genes encoding proteins involved in cell trafficking and the immune response associated with HSCT outcome including graft versus leukemia reaction
  • Risk assessment associated with the “biological experience” of the donor immune system with regards to transplant outcomes and immune reconstitution
  • Organization and international cooperation of voluntary donor and/or cord blood registries

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/bmr/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 212593
  • - Editorial

Biological and Genetic Aspects of Donor-Recipient Matching in HSCT

Andrzej Lange | Colette Raffoux | Bronwen Shaw
  • Special Issue
  • - Volume 2012
  • - Article ID 375075
  • - Clinical Study

CMV Serostatus of Donor-Recipient Pairs Influences the Risk of CMV Infection/Reactivation in HSCT Patients

Emilia Jaskula | Jolanta Bochenska | ... | Andrzej Lange
  • Special Issue
  • - Volume 2012
  • - Article ID 136087
  • - Research Article

Human Leukocyte Antigen Profiles of Latin American Populations: Differential Admixture and Its Potential Impact on Hematopoietic Stem Cell Transplantation

Esteban Arrieta-Bolaños | J. Alejandro Madrigal | Bronwen E. Shaw
  • Special Issue
  • - Volume 2012
  • - Article ID 695018
  • - Review Article

Unrelated Hematopoietic Stem Cell Donor Matching Probability and Search Algorithm

J.-M. Tiercy
  • Special Issue
  • - Volume 2012
  • - Article ID 271695
  • - Review Article

Role of Killer Immunoglobulin-Like Receptor and Ligand Matching in Donor Selection

Meral Beksaç | Klara Dalva
  • Special Issue
  • - Volume 2012
  • - Article ID 257086
  • - Clinical Study

Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors

Monika Dzierzak-Mietla | M. Markiewicz | ... | Slawomira Kyrcz-Krzemien
  • Special Issue
  • - Volume 2012
  • - Article ID 175419
  • - Research Article

Computer Algorithms in the Search for Unrelated Stem Cell Donors

David Steiner
  • Special Issue
  • - Volume 2012
  • - Article ID 539825
  • - Clinical Study

The Presence of Anti-HLA Antibodies before and after Allogeneic Hematopoietic Stem Cells Transplantation from HLA-Mismatched Unrelated Donors

Anna Koclega | Miroslaw Markiewicz | ... | Slawomira Kyrcz-Krzemien
  • Special Issue
  • - Volume 2012
  • - Article ID 873695
  • - Clinical Study

Both Optimal Matching and Procedure Duration Influence Survival of Patients after Unrelated Donor Hematopoietic Stem Cell Transplantation

Sylwia Mizia | Dorota Dera-Joachimiak | ... | Andrzej Lange
  • Special Issue
  • - Volume 2012
  • - Article ID 180391
  • - Review Article

NOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome

Neema P. Mayor | Bronwen E. Shaw | ... | Steven G. E. Marsh

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