Table of Contents
Biotechnology Research International
Volume 2011, Article ID 576286, 11 pages
http://dx.doi.org/10.4061/2011/576286
Review Article

The Use of Endophytes to Obtain Bioactive Compounds and Their Application in Biotransformation Process

1Laboratory of Bioflavors,Department of Food Science, School of Food Engineering, University of Campinas, P.O. Box 6121, 13083-862 Campinas, SP, Brazil
2Laboratory of Nutrition and Metabolism, Department of Food and Nutrition, School of Food Engineering, University of Campinas, P.O. Box 6121, 13083-862 Campinas, SP, Brazil

Received 11 June 2010; Accepted 9 August 2010

Academic Editor: Mohamed A. Al Rubeai

Copyright © 2011 Mariana Recco Pimentel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Endophytes are microorganisms that reside asymptomatically in the tissues of higher plants and are a promising source of novel organic natural metabolites exhibiting a variety of biological activities. The laboratory of Bioaromas (Unicamp, Brazil) develops research in biotransformation processes and functional evaluation of natural products. With the intent to provide subsidies for studies on endophytic microbes related to areas cited before, this paper focuses particularly on the role of endophytes on the production of anticancer, antimicrobial, and antioxidant compounds and includes examples that illustrate their potential for human use. It also describes biotransformation as an auspicious method to obtain novel bioactive compounds from microbes. Biotransformation allows the production of regio- and stereoselective compounds under mild conditions that can be labeled as “natural,” as discussed in this paper.