Research Article

Optimization of Medium Composition for the Production of Neomycin by Streptomyces fradiae NCIM 2418 in Solid State Fermentation

Table 3

Coded and actual values of factors in central composite design.

FactorNameUnits Levels
Axial (−2)Low (−1)Center (0)High (+1)Axial (+2)

Ammonium chloride% w/w1.251.51.752.02.25
Sodium nitrate% w/w1.251.51.752.02.25
L-Histidine% w/w0.1250.250.3750.500.625
Ammonium nitrate% w/w0.1250.250.3750.500.625