Optimization of Medium Composition for the Production of Neomycin by Streptomyces fradiae NCIM 2418 in Solid State Fermentation

Table 4

Central composite design arrangement and responses.

RUN	BLOCK	𝑋10	𝑋9	𝑋8	𝑋11	𝑌 (Neomycin g kg^−1)
1	1	1.50	1.50	0.250	0.500	18567
2	1	1.50	1.50	0.500	0.250	1765
3	1	1.50	2.00	0.250	0.250	18643
4	1	1.50	2.00	0.500	0.500	18347
5	1	2.00	1.50	0.250	0.250	19642
6	1	2.00	1.50	0.500	0.500	4567
7	1	2.00	2.00	0.250	0.500	10754
8	1	2.00	2.00	0.500	0.250	17643
9	1	1.75	1.75	0.375	0.375	15865
10	1	1.75	1.75	0.375	0.375	15164
11	2	1.50	1.50	0.250	0.250	14678
12	2	1.50	1.50	0.500	0.500	1654
13	2	1.50	2.00	0.250	0.500	17543
14	2	1.50	2.00	0.500	0.250	763
15	2	2.00	1.50	0.250	0.500	765
16	2	2.00	1.50	0.500	0.250	1864
17	2	2.00	2.00	0.250	0.250	11543
18	2	2.00	2.00	0.500	0.500	12543
19	2	1.75	1.75	0.375	0.375	7843
20	2	1.75	1.75	0.375	0.375	12356
21	3	1.25	1.75	0.375	0.375	18532
22	3	2.25	1.75	0.375	0.375	12853
23	3	1.75	1.25	0.375	0.375	456
24	3	1.75	2.25	0.375	0.375	17654
25	3	1.75	1.75	0.125	0.375	15432
26	3	1.75	1.75	0.625	0.375	11754
27	3	1.75	1.75	0.375	0.125	12875
28	3	1.75	1.75	0.375	0.625	18743
29	3	1.75	1.75	0.375	0.375	11754
30	3	1.75	1.75	0.375	0.375	17542