Evaluation of Novel Design Strategies for Developing Zinc Finger Nucleases Tools for Treating Human Diseases

<table><tr><td><table class="algorithm" id="figbox2"><tr><td colspan="2">High location specificity + high adherence<svg height="16.8375" id="M38" style="vertical-align:-10.00693pt" version="1.1" viewbox="0 0 22.012501 16.8375" width="22.012501" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,2.9,7.575)"><path d="M901 255q-71 -62 -185 -187l-22 15l102 147h-727v50h727l-102 147l22 15q114 -125 185 -187z" id="x2192"></path></g>
</svg>high reversibility<svg height="16.8375" id="M39" style="vertical-align:-10.00693pt" version="1.1" viewbox="0 0 22.012501 16.8375" width="22.012501" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,2.9,7.575)"><path d="M901 255q-71 -62 -185 -187l-22 15l102 147h-727v50h727l-102 147l22 15q114 -125 185 -187z" id="x2192"></path></g>
</svg></td></tr><tr><td colspan="2">manageable side effects/low–very low toxicity </td></tr></table></td></tr></table>

Biotechnology Research International

figbox2

Box 2

Box 2: Evaluation of Novel Design Strategies for Developing Zinc Finger Nucleases Tools for Treating Human Diseases 