Evaluation of Novel Design Strategies for Developing Zinc Finger Nucleases Tools for Treating Human Diseases

Table 8

Sensitizing the SP1 framework. Potential design strategies for sensitizing versions of the SP1 framework.

1×1st finger	321
2×1st finger	3211
2×3 design	321321
3f + 4f design	3213211
2×4f design	32113211	(to lower affinity and higher specificity)