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Biotechnology Research International
Volume 2015 (2015), Article ID 121735, 13 pages
http://dx.doi.org/10.1155/2015/121735
Review Article

Metagenomics: Retrospect and Prospects in High Throughput Age

1ICAR-National Institute of Abiotic Stress Management, Baramati, Pune, Maharashtra 413115, India
2ICAR-Central Institute of Post-Harvest Engineering and Technology, Abohar Station, Punjab 152116, India

Received 13 July 2015; Accepted 26 October 2015

Academic Editor: Manuel Canovas

Copyright © 2015 Satish Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In recent years, metagenomics has emerged as a powerful tool for mining of hidden microbial treasure in a culture independent manner. In the last two decades, metagenomics has been applied extensively to exploit concealed potential of microbial communities from almost all sorts of habitats. A brief historic progress made over the period is discussed in terms of origin of metagenomics to its current state and also the discovery of novel biological functions of commercial importance from metagenomes of diverse habitats. The present review also highlights the paradigm shift of metagenomics from basic study of community composition to insight into the microbial community dynamics for harnessing the full potential of uncultured microbes with more emphasis on the implication of breakthrough developments, namely, Next Generation Sequencing, advanced bioinformatics tools, and systems biology.